Viral entry into host cells advances in experimental medicine and biology 2013th edition by stefan phlmann editor graham simmons editor be the first to review this item. Stefa n phlmann is professor for infection biology and head of the infection biology unit of the german primate center his research is focused on virus host cell interactions particularly on the molecular processes underlying host cell entry of human immunodeficiency virus and emerging viruses. In general the apn receptor is used by alphacoronaviruses in a species specific manner that is human apn is the cellular receptor for hcov 229e but not for the porcine coronaviruses and conversely porcine apn serves as a receptor for the porcine coronaviruses but not for hcov 229 fcov or ccov 104 105. Beginning with the viral entry into a host cell the book takes the reader through replication of the genome synthesis and assembly of viral structural components genome packaging and maturation into an infectious virion. In the epithelia virus is primed for entry into b cells where a transient growth program is thought to mimic a germinal center reaction ultimately promoting maturation of the infected cell into the peripheral memory b cell compartment advances in next generation sequencing and the development of humanized mice have led to better ways to identify and understand the natural strain variation
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